An unprecedented new program expands on the mission of 60 Days In beyond jail walls, sending undercover participants into the heart of the drug epidemic to expose how far the drug cartels have infiltrated America's Heartland.
Charlie narrowly avoids his cover being blown, but suspicions around him grow; Jenn struggles to connect with her fellow inmates; Jackie takes part in a neighborhood watch and identifies a drug hotspot where she can score.
A CERT raid diverts the inmates' attention away from Charlie; Jackie meets a local "Bonnie and Clyde" and Richie almost blows her cover; Jonathan and Alexis are the final two participants embedded on the streets.
Charlie seizes an opportunity to get closer to his cellmates; the Narcotics Unit raids the residence of one of the largest drug traffickers in Kentucky; Jackie finds an unlikely lead for her investigation; Jenn gains valuable info and passes it to Alexis.
Charlie comes face-to-face with a loaded needle during his initiation with the other inmates; Jenn learns how some of her cellmates smuggle drugs into jail; Jackie discovers a hot spot for cartel activity.
Jonathan and Alexis have their first win trying to disrupt the addiction cycle. In the jail, Charlie uncovers a drug smuggling operation while Jenn starts to become one of the girls.
Jackie's nerves are rattled after a shooting in her trailer park; a fire breaks out in Charlie's pod; Jenn weighs sacrificing her mission for another inmate; Jonathan and Alexis go head-to-head over the sobriety of two recovering addicts.
With the end of the program just days away, participants work overtime to wrap up their missions.