In the city of New Orleans, police officers, fire fighters, and emergency medical technicians working the overnight shift answer as many as a thousand emergency calls every night. Early in this shift, a fleet of police cars and ambulances respond to a report of a man discovered in the street bleeding from multiple gunshot wounds. EMT's Holly and Gavin work furiously to keep the victim alive, rushing him to the hospital, while police flood the neighborhood investigating the shooting and trying to prevent retaliation.
It's an emotional night on the Nightwatch in New Orleans as one EMS officer tells his partner that this is their last night on the job. Meanwhile, it's a tough night in a different way for the fire fighters as the group responds to a call about a truck on fire after a collision at a gas station. It's a night that serves as a reminder that the people of the Nightwatch aren't just there for their city--they're there for each other.
After a quiet beginning of the evening, multiple calls virtually explode across the radio at once--and the most alarming code heard is for "Officer Shot." The overwhelming response to that call leaves EMT's Titus and Dan to endure an agonizing wait for police backup at the scene of a stabbing at a birthday party. Meanwhile, fire fighters respond to the scene of a burning car.
Halloween provides a fitting backdrop to a night on the job that includes some chilling calls. Captain Kevin leads the fire fighters battling a blaze that's engulfed a house, and hopefully nothing more. Police officers Victor and Cedric hunt through a neighborhood in "the country" for a burglary suspect. And on the EMT Sprint Unit, Becca responds to a call she hoped to never get.
Crazy calls abound during a full moon: the victim of a machete hacking, the man whose finger is bitten off by a dog, and more. Meanwhile, two fleet-footed police officers run down suspects and a fire chief faces his fear of rats.
Randy and Justin chase down a suspected car thief, while both EMT teams respond to emergency calls involving children in distress.
Police officers pursue suspected drug dealers, while Keeley saves a group of partiers from a violent schizophrenic.