In Texas, responders run point in a massive multiple car collision. A combative addict and an overdose gone wrong offer tough challenges in New York, while in Louisiana, southern charm is revealed to have its own healing effects.
In Baton Rouge, Lacey and Stacey restrain a patient suffering from violent hallucinations after overdosing; in Yonkers, NY, Alex and Jamal must determine what drug caused a woman to go unresponsive.
Alex and Jamal face unexpected challenges. Steven and Sam are called to a structure fire and must search inside for possible victims. Things get personal for Niki when a call for a patient with back pain takes an emotional turn.
In Austin, Luddy and Finch practice parking lot medicine when they respond to a heroin overdose. Niki and Nicole show their compassionate side to a young woman. After the final call of the night, Yonkers medic Alex reveals a sobering truth about her past.
In Austin, Texas, a man is shot by someone he trusts. Meanwhile, Cunningham and Ariel face an emotional call that hits too close to home. And, Niki and Nicole are faced with the task of trying to save a life of a fellow service member.
A brawl erupts in the back of an ambulance when an overdose patient wakes up swinging. Meanwhile, Ariel and Cunningham rush to the scene of a flaming motorcycle wreck in Yonkers. And, Kim and Audrey hope to find a missing driver at the bottom of a ravine.
Baton Rouge paramedics rush to the aid of a man attacked by his girlfriend with a box-cutter knife. Gunshots fired in Yonkers send Ariel and Cunningham to save a man down. Meanwhile, in Austin, first responders plead with a patient to go the hospital.
A heatwave in the south makes bad calls worse when a man passes out from heat exhaustion and needs intervention before his internal organs shut down. Meanwhile, in Yonkers, Patrick prepares to deliver a baby in the back of the ambulance.
Brandon and Coop race to save a man's life after he's been struck by a bullet in the chest; Austin medics Luddy and Finch encounter the drunkest patient they've ever treated; Alyssa and Kasie are called to a special needs pediatric patient in Baton Rouge.