Keeley treats a man who impaled his hand on a fence, while Titus and Dan have to treat a man stabbed in the face. Titus and Dan race to save an 18-year old shot in the head. Randy and Devin search for suspects in an armed robbery.
A high-speed chase turns into a shootout. Keeley gets called to a woman whose eyeball has been bitten out in a fight. Titus and Dan head to one of the most dangerous projects in the city in order to treat a shooting victim.
Gavin returns from work offshore and is assigned to a new partner, Ted. The SWAT guys head out to serve a high-risk warrant, and Holly, Nick and Keeley respond to a flipped car where the driver's arm is cut to the bone.
The city is in mourning after a well-loved Police officer is shot and killed on duty. Vic and P chase a suspect following an altercation with another officer. Titus and Dan deal with a resisting patient who takes a swing at Titus.
Titus and Dan treat a woman who was viciously stabbed in the face, and Holly and Nick tend to an emotional young transgendered woman who was assaulted. A wild police chase ends with a major car accident.
A woman could lose her arm after a bar fight. Then at the scene of a car accident, a first responder is assaulted while trying to tend to the victims. Police officers catch a teenage bike thief and offer some tough love to get his life on track.
Tommy and Arkady search for a victim who went under in the river; Holly and Nick rush a motorcyclist to the hospital; Titus and Dan assist a pedicab driver with a nasty leg injury; and Randy and Devin search for a drug dealer.
As the first responders do everything they can to save victims of shootings and drug-related offenses and the police chase suspects who end up having illegal firearms, they find themselves asking questions--and only wishing they had the answers.
Police officer Justin leads a raid with the SWAT officers. First responders deal with a man suffering from amnesia after getting hit by a car and a woman who fell off a roof. Arkady bonds with a man who attempted suicide.
Like any dad, Titus wants the best for his son. As an EMT, he sees just how dire life can get. Nights in New Orleans reveal the struggles of life in this city.