The First 48: Missing Persons follows the Chicago Police Department's missing persons unit during an investigation's first 48 hours.
Detectives search for a straight "A" college student. Then, detectives hunt down an alleged gang member who vanished after a drug deal goes bad. And, one detective has just minutes to save the life of a woman who threatens to jump from a bridge.
When a caretaker reports her 63-year-old cancer patient missing, detectives learn the woman has left behind a 15-year-old son. They sift through false sightings, deceitful witnesses and a missing mattress to solve the mystery.
Detectives hunt for a man after his family receives a threat to his life. They must sort through the missing man's troubled family situation and possible drug connections. Next, detectives search for a teenager with a rare sleep disorder.
Detectives search for a 14-year-old girl who has been snatched by a 19-year-old with possible gang connections. Meanwhile, on the hottest day of the year, a detective searches for a missing 66-year-old man with serious neurological problems.
The children of an Iraqi immigrant worry their mother is trying to return to Baghdad. Meanwhile, Detectives Pam Childs and Joe Struck hit the streets in search of a 48-year-old woman who might be a victim of foul play.